Developmental regulation of β1 integrins during angiogenesis in the central nervous system
R Milner, IL Campbell - Molecular and Cellular Neuroscience, 2002 - Elsevier
We examined β1 integrin expression during angiogenesis in the developing mouse CNS.
Maturation of blood vessels was accompanied by three main events:(1) marked
upregulation of β1 integrin expression;(2) a switch in β1 integrin expression, from α4 and α5
at postnatal day 1 to α1 and α6 in the adult; and (3) downregulation of fibronectin and
upregulation of laminin expression. Thus, blood vessel maturation was associated with a
developmental switch, from fibronectin-mediated signaling early in angiogenesis, to laminin …
Maturation of blood vessels was accompanied by three main events:(1) marked
upregulation of β1 integrin expression;(2) a switch in β1 integrin expression, from α4 and α5
at postnatal day 1 to α1 and α6 in the adult; and (3) downregulation of fibronectin and
upregulation of laminin expression. Thus, blood vessel maturation was associated with a
developmental switch, from fibronectin-mediated signaling early in angiogenesis, to laminin …