[HTML][HTML] A streptococcal collagen-like protein interacts with the α2β1 integrin and induces intracellular signaling
JO Humtsoe, JK Kim, Y Xu, DR Keene… - Journal of Biological …, 2005 - ASBMB
The streptococcal collagen-like proteins Scl1 and Scl2 are prokaryotic members of a large
protein family with domains containing the repeating amino acid sequence (Gly-Xaa-Yaa) n
that form a collagen-like triple-helical structure. Here, we test the hypothesis that Scl variant
might interact with mammalian collagen-binding integrins. We show that the recombinant Scl
protein p176 promotes adhesion and spreading of human lung fibroblast cells through an α
2 β 1 integrin-mediated interaction as shown in cell adhesion inhibition assays using anti-α …
protein family with domains containing the repeating amino acid sequence (Gly-Xaa-Yaa) n
that form a collagen-like triple-helical structure. Here, we test the hypothesis that Scl variant
might interact with mammalian collagen-binding integrins. We show that the recombinant Scl
protein p176 promotes adhesion and spreading of human lung fibroblast cells through an α
2 β 1 integrin-mediated interaction as shown in cell adhesion inhibition assays using anti-α …