[HTML][HTML] Changing ligand specificities of αvβ1 and αvβ3 integrins by swapping a short diverse sequence of the β subunit
J Takagi, T Kamata, J Meredith… - Journal of Biological …, 1997 - ASBMB
Integrins mediate signal transduction through interaction with multiple cellular or
extracellular matrix ligands. Integrin αvβ3 recognizes fibrinogen, von Willebrand factor, and
vitronectin, while αvβ1 does not. We studied the mechanisms for defining ligand specificity of
these integrins by swapping the highly diverse sequences in the I domain-like structure of
the β1 and β3 subunits. When the sequence CTSEQNC (residues 187–193) of β1 is
replaced with the corresponding CYDMKTTC sequence of β3, the ligand specificity of αvβ1 …
extracellular matrix ligands. Integrin αvβ3 recognizes fibrinogen, von Willebrand factor, and
vitronectin, while αvβ1 does not. We studied the mechanisms for defining ligand specificity of
these integrins by swapping the highly diverse sequences in the I domain-like structure of
the β1 and β3 subunits. When the sequence CTSEQNC (residues 187–193) of β1 is
replaced with the corresponding CYDMKTTC sequence of β3, the ligand specificity of αvβ1 …