[HTML][HTML] Pharmacoproteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis
P11, a novel peptide ligand containing a PDZ-binding motif (Ser-Asp-Val) with high affinity to
integrin α v β 3 was identified from a hexapeptide library (PS-SPCL) using a protein
microarray chip-based screening system. Here, we investigated the inhibitory mechanism of
P11 (HSDVHK) on tumor-induced angiogenesis via a pharmacoproteomic approach. P11
was rapidly internalized by, human umbilical vein endothelial cells (HUVECs) via an integrin
α v β 3-mediated event. Caveolin and clathrin appeared to be involved in the P11 uptake …
integrin α v β 3 was identified from a hexapeptide library (PS-SPCL) using a protein
microarray chip-based screening system. Here, we investigated the inhibitory mechanism of
P11 (HSDVHK) on tumor-induced angiogenesis via a pharmacoproteomic approach. P11
was rapidly internalized by, human umbilical vein endothelial cells (HUVECs) via an integrin
α v β 3-mediated event. Caveolin and clathrin appeared to be involved in the P11 uptake …