Nasal gene expression of angiotensin-converting enzyme 2 in children and adults
S Bunyavanich, A Do, A Vicencio - Jama, 2020 - jamanetwork.com
We found age-dependent ACE2 gene expression in nasal epithelium (Figure). ACE2 gene
expression was lowest (mean log2 counts per million, 2.40; 95% CI, 2.07-2.72) in younger
children (n= 45) and increased with age, with mean log2 counts per million of 2.77 (95% CI,
2.64-2.90) for older children (n= 185), 3.02 (95% CI, 2.78-3.26) for young adults (n= 46), and
3.09 (95% CI, 2.83-3.35) for adults (n= 29). Linear regression with ACE2 gene expression as
the dependent variable and age group as the independent variable showed that compared …
expression was lowest (mean log2 counts per million, 2.40; 95% CI, 2.07-2.72) in younger
children (n= 45) and increased with age, with mean log2 counts per million of 2.77 (95% CI,
2.64-2.90) for older children (n= 185), 3.02 (95% CI, 2.78-3.26) for young adults (n= 46), and
3.09 (95% CI, 2.83-3.35) for adults (n= 29). Linear regression with ACE2 gene expression as
the dependent variable and age group as the independent variable showed that compared …