[HTML][HTML] The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer
CY Sun, D Cao, BB Du, CW Chen… - International Journal of …, 2022 - ncbi.nlm.nih.gov
CY Sun, D Cao, BB Du, CW Chen, D Liu
International Journal of Biological Sciences, 2022•ncbi.nlm.nih.govRNA can be modified by over 170 types of distinct chemical modifications, and the most
abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The
m 6 A modification accelerates mRNA process, including mRNA splicing, translation,
transcript stability, export and decay. m 6 A RNA modification is installed by
methyltransferase-like proteins (writers), and potentially removed by demethylases
(erasers), and this process is recognized by m 6 A-binding proteins (readers). Notably …
abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The
m 6 A modification accelerates mRNA process, including mRNA splicing, translation,
transcript stability, export and decay. m 6 A RNA modification is installed by
methyltransferase-like proteins (writers), and potentially removed by demethylases
(erasers), and this process is recognized by m 6 A-binding proteins (readers). Notably …
Abstract
RNA can be modified by over 170 types of distinct chemical modifications, and the most abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The m 6 A modification accelerates mRNA process, including mRNA splicing, translation, transcript stability, export and decay. m 6 A RNA modification is installed by methyltransferase-like proteins (writers), and potentially removed by demethylases (erasers), and this process is recognized by m 6 A-binding proteins (readers). Notably, alterations of m 6 A-modified proteins (writers, erasers and readers) are involved in the tumorigenesis, progression and metastasis. Importantly, the fate of m 6 A-methylated mRNA is mediated mostly through m 6 A readers, and among these readers, insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) are unique RNA-binding proteins (RBPs) that stabilize their targets mRNA via m 6 A modification. In this review, we update the writers, erasers and readers, and their cross-talks in m 6 A modification, and briefly discuss the oncogenic role of IGF2BPs in cancer. Most importantly, we mainly review the up-to-date knowledges of IGF2BPs (IGF2BP1/2/3) as m 6 A readers in an m 6 A-modified manner in cancer progression.
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