Delivery methods to increase cellular uptake and immunogenicity of DNA vaccines
SHT Jorritsma, EJ Gowans, B Grubor-Bauk… - Vaccine, 2016 - Elsevier
Vaccine, 2016•Elsevier
DNA vaccines are ideal candidates for global vaccination purposes because they are
inexpensive and easy to manufacture on a large scale such that even people living in low-
income countries can benefit from vaccination. However, the potential of DNA vaccines has
not been realized owing mainly to the poor cellular uptake of DNA in vivo resulting in the
poor immunogenicity of DNA vaccines. In this review, we discuss the benefits and
shortcomings of several promising and innovative non-biological methods of DNA delivery …
inexpensive and easy to manufacture on a large scale such that even people living in low-
income countries can benefit from vaccination. However, the potential of DNA vaccines has
not been realized owing mainly to the poor cellular uptake of DNA in vivo resulting in the
poor immunogenicity of DNA vaccines. In this review, we discuss the benefits and
shortcomings of several promising and innovative non-biological methods of DNA delivery …
Abstract
DNA vaccines are ideal candidates for global vaccination purposes because they are inexpensive and easy to manufacture on a large scale such that even people living in low-income countries can benefit from vaccination. However, the potential of DNA vaccines has not been realized owing mainly to the poor cellular uptake of DNA in vivo resulting in the poor immunogenicity of DNA vaccines. In this review, we discuss the benefits and shortcomings of several promising and innovative non-biological methods of DNA delivery that can be used to increase cellular delivery and efficacy of DNA vaccines.
Elsevier