The plastic architecture of the mitochondrial network and its dynamic structure play crucial
roles ensuring that varying energetic demands are rapidly met. Given the brain's high
energy demand, mitochondria play a particularly critical role in neuronal and axonal energy
homeostasis. With ageing physiological properties of the organism deteriorate, and are
associated with loss of cellular homeostasis, accumulation of dysfunctional organelles and
damaged macromolecules. Thus, mitochondrial loss of efficiency is likely to be both a cause …