[HTML][HTML] A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis
H Ma, M Zeng, Y Han, H Yan, H Tang, J Sheng, H Hu… - Medicine, 2016 - journals.lww.com
Aim: Tauroursodeoxycholic acid (TUDCA) is a taurine conjugated form of ursodeoxycholic
acid (UDCA) with higher hydrophility. To further evaluate the efficacy and safety of TUDCA
for primary biliary cholangitis (PBC), we performed this study on Chinese patients. Methods:
199 PBC patients were randomly assigned to either 250 mg TUDCA plus UDCA placebo or
250 mg UDCA plus TUDCA placebo, 3 times per day for 24 weeks. The primary endpoint
was defined as percentage of patients achieving serum alkaline phosphatase (ALP) …
acid (UDCA) with higher hydrophility. To further evaluate the efficacy and safety of TUDCA
for primary biliary cholangitis (PBC), we performed this study on Chinese patients. Methods:
199 PBC patients were randomly assigned to either 250 mg TUDCA plus UDCA placebo or
250 mg UDCA plus TUDCA placebo, 3 times per day for 24 weeks. The primary endpoint
was defined as percentage of patients achieving serum alkaline phosphatase (ALP) …