Mutual regulation and balance between the endocrine and immune systems facilitate an
organism's stress response and are impaired following chronic stress or prolonged immune
activation. Concurrent alterations in stress physiology and immunity are increasingly
recognized as contributing factors to several stress-linked neuropsychiatric disorders
including depression, anxiety, and post-traumatic stress disorder. Accumulating evidence
suggests that impaired balance and crosstalk between the glucocorticoid receptor (GR) and …