Stable synaptic retention of serine-880-phosphorylated GluR2 in hippocampal neurons
BA States, L Khatri, EB Ziff - Molecular and Cellular Neuroscience, 2008 - Elsevier
Phosphorylation of S880 within the GluR2 C-terminus has been reported to promote
endocytosis of AMPA receptors (AMPARs) by preventing GluR2 interaction with the putative
synaptic anchoring proteins GRIP and ABP. It is not yet established however, whether S880
phosphorylation induces removal of AMPARs from synaptic sites, and the trafficking of
phosphorylated GluR2 subunits with surface and endocytosed GluR2 has not been directly
compared within the same intact neurons. Here we show that phosphorylation of GluR2 …
endocytosis of AMPA receptors (AMPARs) by preventing GluR2 interaction with the putative
synaptic anchoring proteins GRIP and ABP. It is not yet established however, whether S880
phosphorylation induces removal of AMPARs from synaptic sites, and the trafficking of
phosphorylated GluR2 subunits with surface and endocytosed GluR2 has not been directly
compared within the same intact neurons. Here we show that phosphorylation of GluR2 …