Fast interaction between AMPA and NMDA receptors by intracellular calcium
A Rozov, N Burnashev - Cell Calcium, 2016 - Elsevier
Suppression of NMDA receptor (NMDAR)-mediated currents by intracellular Ca 2+ has been
described as a negative feedback loop in NMDAR modulation. In the time scale of tenths of
milliseconds the depth of the suppression does not depend on the Ca 2+ source. It may be
caused by Ca 2+ influx through voltage-gated calcium channels, NMDAR channels or
release from intracellular stores. However, NMDARs are often co-expressed in synapses
with Ca 2+-permeable AMPA receptors (AMPARs). Due to significant differences in …
described as a negative feedback loop in NMDAR modulation. In the time scale of tenths of
milliseconds the depth of the suppression does not depend on the Ca 2+ source. It may be
caused by Ca 2+ influx through voltage-gated calcium channels, NMDAR channels or
release from intracellular stores. However, NMDARs are often co-expressed in synapses
with Ca 2+-permeable AMPA receptors (AMPARs). Due to significant differences in …