A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way
We have previously reported that an episode of pentylenetetrazole (PTZ)-induced status
epilepticus (SE) in immature rats induces a long-term increase in cholinergic excitation
assessed in the adult brain in vitro. In this in vivo work, we tested the responsiveness of adult
SE-conditioned rats to pilocarpine and PTZ, two convulsants with different mechanisms of
action. Postnatal day (P) 20 Sprague-Dawley juvenile rats were conditioned by an episode
of PTZ-induced SE (ie a stage 5 seizure of≥ 20 min, SE-rats). These and their untreated …
epilepticus (SE) in immature rats induces a long-term increase in cholinergic excitation
assessed in the adult brain in vitro. In this in vivo work, we tested the responsiveness of adult
SE-conditioned rats to pilocarpine and PTZ, two convulsants with different mechanisms of
action. Postnatal day (P) 20 Sprague-Dawley juvenile rats were conditioned by an episode
of PTZ-induced SE (ie a stage 5 seizure of≥ 20 min, SE-rats). These and their untreated …