NBQX or topiramate treatment after perinatal hypoxia‐induced seizures prevents later increases in seizure‐induced neuronal injury
S Koh, FD Tibayan, JN Simpson, FE Jensen - Epilepsia, 2004 - Wiley Online Library
S Koh, FD Tibayan, JN Simpson, FE Jensen
Epilepsia, 2004•Wiley Online LibraryPurpose: To evaluate the efficacy of NBQX (2, 3‐dihydroxy‐6‐nitro‐7‐sulfamoylbenzo (f)
quinoxaline‐2, 3‐dione) and topiramate (TPM) given after hypoxia‐induced seizures in
preventing the delayed effect of hypoxia on subsequent susceptibility to seizures and
neuronal injury. Methods: We used “two‐hit” rodent seizure model to study the long‐term
effect of perinatal hypoxia on later kainate (KA) seizure‐induced neuronal damage and
investigated the therapeutic efficacy of a postseizure treatment protocol in reversing the …
quinoxaline‐2, 3‐dione) and topiramate (TPM) given after hypoxia‐induced seizures in
preventing the delayed effect of hypoxia on subsequent susceptibility to seizures and
neuronal injury. Methods: We used “two‐hit” rodent seizure model to study the long‐term
effect of perinatal hypoxia on later kainate (KA) seizure‐induced neuronal damage and
investigated the therapeutic efficacy of a postseizure treatment protocol in reversing the …
Summary
Purpose: To evaluate the efficacy of NBQX (2,3‐dihydroxy‐6‐nitro‐7‐sulfamoylbenzo(f) quinoxaline‐2,3‐dione) and topiramate (TPM) given after hypoxia‐induced seizures in preventing the delayed effect of hypoxia on subsequent susceptibility to seizures and neuronal injury.
Methods: We used “two‐hit” rodent seizure model to study the long‐term effect of perinatal hypoxia on later kainate (KA) seizure‐induced neuronal damage and investigated the therapeutic efficacy of a postseizure treatment protocol in reversing the conditioning effect of early‐life seizures.
Results: Hypoxia at P10 induces seizures without cell death but causes an increase in susceptibility to second seizures induced by KA as early as 96 h after hypoxia, and this lowered seizure threshold persists to adulthood. Furthermore, perinatal hypoxia increases KA‐induced neuronal injury at postnatal day (P)21 and 28/30. Repeated doses of NBQX (20 mg/kg) or TPM (30 mg/kg) given for 48 h after hypoxia‐induced seizures prevent the increase in susceptibility to KA seizure‐induced hippocampal neuronal injury at P28/30.
Conclusions: Our results suggest that α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionate (AMPA) receptor blockade after hypoxia prevents the priming effect of perinatal hypoxia‐induced seizures and that this protection occurs independent of its anticonvulsant action.
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