Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures
CE Stafstrom, JL Thompson, GL Holmes - Developmental Brain Research, 1992 - Elsevier
Acute and chronic effects of seizures induced by intraperitoneal (ip) injection of kainic acid
(KA) were studied in developing rats (postnatal days (P) 5, 10, 20, 30, and adult 60). For 3
months following KA-induced status epilepticus, spontaneous recurrent seizure (SRS)
occurrence was quantified using intermittent video monitoring. Latency to generalized
seizures was then tested using flurothyl, and brains were histologically analyzed for CA3
lesions. In P5–10 rats, KA caused generalized tonic-clonic ('swimming') seizures. SRS did …
(KA) were studied in developing rats (postnatal days (P) 5, 10, 20, 30, and adult 60). For 3
months following KA-induced status epilepticus, spontaneous recurrent seizure (SRS)
occurrence was quantified using intermittent video monitoring. Latency to generalized
seizures was then tested using flurothyl, and brains were histologically analyzed for CA3
lesions. In P5–10 rats, KA caused generalized tonic-clonic ('swimming') seizures. SRS did …