Early life seizures: evidence for chronic deficits linked to autism and intellectual disability across species and models
PB Bernard, TA Benke - Experimental neurology, 2015 - Elsevier
PB Bernard, TA Benke
Experimental neurology, 2015•ElsevierAbstract Recent work in Exp Neurol by Lugo et al.(2014b) demonstrated chronic alterations
in sociability, learning and memory following multiple early life seizures (ELS) in a mouse
model. This work adds to the growing body of evidence supporting the detrimental nature of
ELS on the developing brain to contribute to aspects of an autistic phenotype with
intellectual disability. Review of the face validity of behavioral testing and the construct
validity of the models used informs the predictive ability and thus the utility of these models …
in sociability, learning and memory following multiple early life seizures (ELS) in a mouse
model. This work adds to the growing body of evidence supporting the detrimental nature of
ELS on the developing brain to contribute to aspects of an autistic phenotype with
intellectual disability. Review of the face validity of behavioral testing and the construct
validity of the models used informs the predictive ability and thus the utility of these models …
Abstract
Recent work in Exp Neurol by Lugo et al. (2014b) demonstrated chronic alterations in sociability, learning and memory following multiple early life seizures (ELS) in a mouse model. This work adds to the growing body of evidence supporting the detrimental nature of ELS on the developing brain to contribute to aspects of an autistic phenotype with intellectual disability. Review of the face validity of behavioral testing and the construct validity of the models used informs the predictive ability and thus the utility of these models to translate underlying molecular and cellular mechanisms into future human studies.
Elsevier