Accumulation of amyloid beta (Aβ) soluble forms in the cerebral parenchyma is the
mainstream concept underlying memory deficit in the early phase of Alzheimer's disease
(AD). PKMζ plays a critical role in the maintenance of long-term memory. Yet, the role of this
brain-specific enzyme has not been addressed in AD. We examined the impact of
hippocampal PKMζ overexpression on AD-related memory impairment in rats. Oligomeric
form of Aβ (oAβ) or vehicle was bilaterally microinjected into the dorsal hippocampus of …