Asymmetric delivery and distribution of macromolecules are essential for cell polarity and for
cellular functions such as differentiation, division, and signaling. Injury of podocytes, which
are polarized epithelial cells, changes the dynamics of the actin meshwork, resulting in foot
process retraction and proteinuria. Although the spatiotemporal control of specific protein–
protein interactions is crucial for the establishment of cell polarity, the mechanisms
controlling polarity-dependent differentiation and division are incompletely understood. In …