KIBRA: In the brain and beyond
L Zhang, S Yang, DO Wennmann, Y Chen… - Cellular signalling, 2014 - Elsevier
L Zhang, S Yang, DO Wennmann, Y Chen, J Kremerskothen, J Dong
Cellular signalling, 2014•ElsevierIn mammals, the KIBRA locus has been associated with memory performance and cognition
by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila
and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway,
which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA
is involved in other physiological processes including cell polarity, membrane/vesicular
trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly …
by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila
and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway,
which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA
is involved in other physiological processes including cell polarity, membrane/vesicular
trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly …
Abstract
In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.
Elsevier