Interactions of IGF‐II with the IGF2R/Cation‐Independent Mannose‐6‐Phosphate Receptor: Mechanism and Biological Outcomes
Abstract The cation‐independent mannose‐6‐phosphate/insulin‐like growth factor‐II
receptor (IGF2R) is a membrane‐bound glycoprotein consisting of 15 homologous
extracellular repeat domains. The major function of this receptor is trafficking of lysosomal
enzymes from the trans‐Golgi network to the endosomes and their subsequent transfer to
lysosomes. The IGF2R also plays a major role in binding and regulating the circulating and
tissue levels of IGF‐II. As this ligand is important for cell growth, survival, and migration, the …
receptor (IGF2R) is a membrane‐bound glycoprotein consisting of 15 homologous
extracellular repeat domains. The major function of this receptor is trafficking of lysosomal
enzymes from the trans‐Golgi network to the endosomes and their subsequent transfer to
lysosomes. The IGF2R also plays a major role in binding and regulating the circulating and
tissue levels of IGF‐II. As this ligand is important for cell growth, survival, and migration, the …
