[HTML][HTML] The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
H Bräuner-Osborne, AA Jensen, PO Sheppard… - Journal of Biological …, 1999 - ASBMB
The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that displays 19–25%
sequence identity to the γ-aminobutyric acid type B (GABA B) and metabotropic glutamate
(mGlu) receptors. All three groups of receptors have a large amino-terminal domain (ATD),
which for the mGlu receptors has been shown to bind the endogenous agonist. To
investigate whether the agonist-binding domain of the CaR also is located in the ATD, we
constructed a chimeric receptor named Ca/1a consisting of the ATD of CaR and the seven …
sequence identity to the γ-aminobutyric acid type B (GABA B) and metabotropic glutamate
(mGlu) receptors. All three groups of receptors have a large amino-terminal domain (ATD),
which for the mGlu receptors has been shown to bind the endogenous agonist. To
investigate whether the agonist-binding domain of the CaR also is located in the ATD, we
constructed a chimeric receptor named Ca/1a consisting of the ATD of CaR and the seven …
