The cell surface calcium receptor (Ca2+ receptor) is a particularly difficult receptor to study
because its primary physiological ligand, Ca2+, affects numerous biological processes both
within and outside of cells. Because of this, distinguishing effects of extracellular Ca2+
mediated by the Ca2+ receptor from those mediated by other mechanisms is challenging.
Certain pharmacological approaches, however, when combined with appropriate
experimental designs, can be used to more confidently identify cellular responses regulated …