[HTML][HTML] CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail
L Rusconi, L Salvatoni, L Giudici, I Bertani… - Journal of Biological …, 2008 - ASBMB
Mutations in the human X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been
identified in patients with Rett syndrome (RTT), West syndrome, and X-linked infantile
spasms, sharing the common feature of mental retardation and early seizures. CDKL5 is a
rather uncharacterized kinase, but its involvement in RTT seems to be explained by the fact
that it works upstream of MeCP2, the main cause of Rett syndrome. To understand the role
of this kinase for nervous system functions and to address if molecular mechanisms are …
identified in patients with Rett syndrome (RTT), West syndrome, and X-linked infantile
spasms, sharing the common feature of mental retardation and early seizures. CDKL5 is a
rather uncharacterized kinase, but its involvement in RTT seems to be explained by the fact
that it works upstream of MeCP2, the main cause of Rett syndrome. To understand the role
of this kinase for nervous system functions and to address if molecular mechanisms are …