[HTML][HTML] Common sources of inflammation and their impact on hematopoietic stem cell biology
D Hormaechea-Agulla, DT Le, KY King - Current stem cell reports, 2020 - Springer
D Hormaechea-Agulla, DT Le, KY King
Current stem cell reports, 2020•SpringerAbstract Purpose of Review Inflammatory signals have emerged as critical regulators of
hematopoietic stem cell (HSC) function. Specifically, HSCs are highly responsive to acute
changes in systemic inflammation and this influences not only their division rate but also
their lineage fate. Identifying how inflammation regulates HSCs and shapes the blood
system is crucial to understanding the mechanisms underpinning these processes, as well
as potential links between them. Recent Findings A widening array of physiologic and …
hematopoietic stem cell (HSC) function. Specifically, HSCs are highly responsive to acute
changes in systemic inflammation and this influences not only their division rate but also
their lineage fate. Identifying how inflammation regulates HSCs and shapes the blood
system is crucial to understanding the mechanisms underpinning these processes, as well
as potential links between them. Recent Findings A widening array of physiologic and …
Purpose of Review
Inflammatory signals have emerged as critical regulators of hematopoietic stem cell (HSC) function. Specifically, HSCs are highly responsive to acute changes in systemic inflammation and this influences not only their division rate but also their lineage fate. Identifying how inflammation regulates HSCs and shapes the blood system is crucial to understanding the mechanisms underpinning these processes, as well as potential links between them.
Recent Findings
A widening array of physiologic and pathologic processes involving heightened inflammation are now recognized to critically affect HSC biology and blood lineage production. Conditions documented to affect HSC function include not only acute and chronic infections but also autoinflammatory conditions, irradiation injury, and physiologic states such as aging and obesity.
Summary
Recognizing the contexts during which inflammation affects primitive hematopoiesis is essential to improving our understanding of HSC biology and informing new therapeutic interventions against maladaptive hematopoiesis that occurs during inflammatory diseases, infections, and cancer-related disorders.
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