Effect of estrogen on brain activation patterns in postmenopausal women during working memory tasks
SE Shaywitz, BA Shaywitz, KR Pugh, RK Fulbright… - Jama, 1999 - jamanetwork.com
ContextPreclinical studies suggest that estrogen affects neural structure and function in
mature animals; clinical studies are less conclusive with many, but not all, studies showing a
positive influence of estrogen on verbal memory in postmenopausal women. ObjectiveTo
investigate the effects of estrogen on brain activation patterns in postmenopausal women as
they performed verbal and nonverbal working memory tasks. DesignRandomized, double-
blind, placebo-controlled, crossover trial from 1996 through 1998. SettingCommunity …
mature animals; clinical studies are less conclusive with many, but not all, studies showing a
positive influence of estrogen on verbal memory in postmenopausal women. ObjectiveTo
investigate the effects of estrogen on brain activation patterns in postmenopausal women as
they performed verbal and nonverbal working memory tasks. DesignRandomized, double-
blind, placebo-controlled, crossover trial from 1996 through 1998. SettingCommunity …