Neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark of gastrointestinal
inflammation, with significant implications for host defense, injury and repair. However,
phenotypic and mechanistic aspects of PMN recruitment in inflamed intestines have not
been explored in vivo. Using novel epithelial/PMN fluorescence reporter mice, advanced
intravital imaging and 3D reconstruction analysis, we mapped the microvasculature
architecture across the intestinal layers and determined that in response to …