Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components
N Stahl, TG Boulton, T Farruggella, NY Ip, S Davis… - Science, 1994 - science.org
Science, 1994•science.org
A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF),
leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-
Tyk family of cytoplasmic tyrosine kinases. The β receptor components for this cytokine
family, gp130 and LIF receptor β, constitutively associate with Jak-Tyk kinases. Activation of
these kinases occurs as a result of ligand-induced dimerization of the receptor β
components. Unlike other cytokine receptors studied to date, the receptors for the CNTF …
leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-
Tyk family of cytoplasmic tyrosine kinases. The β receptor components for this cytokine
family, gp130 and LIF receptor β, constitutively associate with Jak-Tyk kinases. Activation of
these kinases occurs as a result of ligand-induced dimerization of the receptor β
components. Unlike other cytokine receptors studied to date, the receptors for the CNTF …
A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The β receptor components for this cytokine family, gp130 and LIF receptor β, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor β components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.
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