Complement C5a in the sepsis syndrome—too much of a good thing?
C Gerard - New England Journal of Medicine, 2003 - Mass Medical Soc
C Gerard
New England Journal of Medicine, 2003•Mass Medical SocIn sepsis, activation of the complement system introduces large amounts of C5a into the
circulation. The excess of this peptide paralyzes neutrophils and increases susceptibility to
infection. In tissues, by contrast, C5a has effects on neutrophils that protect against infection.
Neutralization of circulating C5a by an antibody protects against the lethal effects of sepsis
in an animal model.
circulation. The excess of this peptide paralyzes neutrophils and increases susceptibility to
infection. In tissues, by contrast, C5a has effects on neutrophils that protect against infection.
Neutralization of circulating C5a by an antibody protects against the lethal effects of sepsis
in an animal model.
In sepsis, activation of the complement system introduces large amounts of C5a into the circulation. The excess of this peptide paralyzes neutrophils and increases susceptibility to infection. In tissues, by contrast, C5a has effects on neutrophils that protect against infection. Neutralization of circulating C5a by an antibody protects against the lethal effects of sepsis in an animal model.
The New England Journal Of Medicine