[HTML][HTML] A single-cell lung atlas of complement genes identifies the mesothelium and epithelium as prominent sources of extrahepatic complement proteins
N Chaudhary, A Jayaraman, C Reinhardt… - Mucosal …, 2022 - Elsevier
To understand functional duality of the complement system in host defense and lung injury,
a more comprehensive view of its localized production in the lung, and the impact of age on
complement production are essential. Here, we explored the expression of complement
genes through computational analysis of preexisting single cell RNA sequencing data from
lung transcriptomes of healthy young (3 months) and old C57BL/6 mice (24 months), and
humans. We characterized the distribution of 48 complement genes. Across 28 distinct …
a more comprehensive view of its localized production in the lung, and the impact of age on
complement production are essential. Here, we explored the expression of complement
genes through computational analysis of preexisting single cell RNA sequencing data from
lung transcriptomes of healthy young (3 months) and old C57BL/6 mice (24 months), and
humans. We characterized the distribution of 48 complement genes. Across 28 distinct …