Results

Patients were screened between January 1, 2021 and July 30, 2021. A total of 43,093 patients were evaluated in the study site’s emergency department during the enrollment period (Supplementary Figure S1 A). During the same time period, 1056 new cases of COVID-19 infection were diagnosed (Supplementary Figure S1 B). A total of 114 patients (10.8% of admitted) met the criteria for enrollment (Supplementary Figure S1 C). Thirteen (11.4% of screened) patients identified to have COVID-19 infection were enrolled in the study (Table 1, Supplementary Table S1), including 4 patients with solid organ transplants (Table 1, Supplementary Table S1). Six patients were randomized to receive ravulizumab in addition to standard of care (SOC+ R) and 7 patients were randomized to SOC.