Hepatocyte growth factor induces collagenase (matrix metalloproteinase-1) via the transcription factor Ets-1 in human hepatic stellate cell line
I Ozaki, G Zhao, T Mizuta, Y Ogawa, T Hara… - Journal of …, 2002 - Elsevier
Background/Aims: Although hepatocyte growth factor recently has been shown to decrease
hepatic fibrosis in animal models, the molecular mechanisms of this effects remain to be
elucidated. We investigated regulation of collagenase expression by hepatocyte growth
factor in hepatic stellate cells. Methods: A human hepatic stellate cell line, LI90, was treated
with hepatocyte growth factor. Expression of collagenase, 72 kDa gelatinase, procollagen
α1 (I), tissue inhibitor of matrix metalloproteinase-1, transforming growth factor-β1, or Ets-1 …
hepatic fibrosis in animal models, the molecular mechanisms of this effects remain to be
elucidated. We investigated regulation of collagenase expression by hepatocyte growth
factor in hepatic stellate cells. Methods: A human hepatic stellate cell line, LI90, was treated
with hepatocyte growth factor. Expression of collagenase, 72 kDa gelatinase, procollagen
α1 (I), tissue inhibitor of matrix metalloproteinase-1, transforming growth factor-β1, or Ets-1 …