[HTML][HTML] Characterization of ΔN-Zfp36l2 mutant associated with arrest of early embryonic development and female infertility
SBV Ramos - Journal of Biological Chemistry, 2012 - ASBMB
The zinc finger protein 36-like 2, Zfp36l2, has been implicated in female mouse infertility,
because an amino-terminal truncation mutation (ΔN-Zfp36l2) leads to two-cell stage arrest of
embryos derived from the homozygous mutant female gamete. Zfp36l2 is a member of the
tristetraprolin (TTP) family of CCCH tandem zinc finger proteins that can bind to transcripts
containing AU-rich elements (ARE), resulting in deadenylation and destabilization of these
transcripts. I show here that the mouse Zfp36l2 is composed of two exons and a single …
because an amino-terminal truncation mutation (ΔN-Zfp36l2) leads to two-cell stage arrest of
embryos derived from the homozygous mutant female gamete. Zfp36l2 is a member of the
tristetraprolin (TTP) family of CCCH tandem zinc finger proteins that can bind to transcripts
containing AU-rich elements (ARE), resulting in deadenylation and destabilization of these
transcripts. I show here that the mouse Zfp36l2 is composed of two exons and a single …