[HTML][HTML] Activation of sphingosine-1-phosphate receptor 1 in the spinal cord produces mechanohypersensitivity through the activation of inflammasome and IL-1β …
TM Doyle, Z Chen, M Durante, D Salvemini - The journal of pain, 2019 - Elsevier
Abstract Sphingosine-1-phosphate (S1P) receptor 1 subtype (S1PR1) activation by its ligand
S1P in the dorsal horn of the spinal cord causes mechanohypersensitivity. The cellular and
molecular pathways remain poorly understood. We report that the activation of S1PR1 with
an intrathecal injection of the highly selective S1PR1 agonist SEW2871 led to the
development of mechanoallodynia by activating the nod-like receptor family, pyrin domain
containing 3 (NLRP3) inflammasome (increased expression of NLRP3, cleaved caspase 1 …
S1P in the dorsal horn of the spinal cord causes mechanohypersensitivity. The cellular and
molecular pathways remain poorly understood. We report that the activation of S1PR1 with
an intrathecal injection of the highly selective S1PR1 agonist SEW2871 led to the
development of mechanoallodynia by activating the nod-like receptor family, pyrin domain
containing 3 (NLRP3) inflammasome (increased expression of NLRP3, cleaved caspase 1 …
