Aberrant expression, activation, and stabilization of epidermal growth factor receptor (EGFR)
are causally associated with several human cancers. Post-translational modifications and
protein-protein interactions directly modulate the signaling and trafficking of the EGFR.
Activated EGFR is internalized by endocytosis and then either recycled back to the cell
surface or degraded in the lysosome. EGFR internalization and recycling also occur in
response to stresses that activate p38 MAP kinase. Mass spectrometry was applied to …