Autoimmune polyglandular diseases (APD) are defined as the presence of two autoimmune–
induced endocrine failures. With respect to the significant morbidity and potential mortality of
APD, the diagnostic objective is to detect APD at an early stage, with the advantage of less
frequent complications, effective therapy and better prognosis. This requires that patients at
risk be regularly screened for subclinical endocrinopathies prior to clinical manifestation.
Regarding the time interval between manifestation of first and further endocrinopathies …