Regulation of blood–testis barrier (BTB) dynamics during spermatogenesis via the “Yin” and “Yang” effects of mammalian target of rapamycin complex 1 (mTORC1) …
KW Mok, DD Mruk, CY Cheng - International review of cell and molecular …, 2013 - Elsevier
In mammalian testes, haploid spermatozoa are formed from diploid spermatogonia during
spermatogenesis, which is a complicated cellular process. While these cellular events were
reported in the 1960s and 1970s, the underlying molecular mechanism (s) that regulates
these events remained unexplored until the past∼ 10 years. For instance, adhesion proteins
were shown to be integrated components at the Sertoli cell–cell interface and/or the Sertoli–
spermatid interface in the late 1980s. But only until recently, studies have demonstrated that …
spermatogenesis, which is a complicated cellular process. While these cellular events were
reported in the 1960s and 1970s, the underlying molecular mechanism (s) that regulates
these events remained unexplored until the past∼ 10 years. For instance, adhesion proteins
were shown to be integrated components at the Sertoli cell–cell interface and/or the Sertoli–
spermatid interface in the late 1980s. But only until recently, studies have demonstrated that …