Peculiar phenotypic and cytotoxic features of pulmonary mucosal CD8 T cells in people living with HIV receiving long-term antiretroviral therapy
O Meziane, Y Alexandrova, R Olivenstein… - The Journal of …, 2021 - journals.aai.org
People living with HIV have high burdens of chronic lung disease, lung cancers, and
pulmonary infections despite antiretroviral therapy (ART). The rates of tobacco smoking by
people living with HIV vastly exceed that of the general population. Furthermore, we showed
that HIV can persist within the lung mucosa despite long-term ART. As CD8 T cell cytotoxicity
is pivotal for controlling viral infections and eliminating defective cells, we explored the
phenotypic and functional features of pulmonary versus peripheral blood CD8 T cells in ART …
pulmonary infections despite antiretroviral therapy (ART). The rates of tobacco smoking by
people living with HIV vastly exceed that of the general population. Furthermore, we showed
that HIV can persist within the lung mucosa despite long-term ART. As CD8 T cell cytotoxicity
is pivotal for controlling viral infections and eliminating defective cells, we explored the
phenotypic and functional features of pulmonary versus peripheral blood CD8 T cells in ART …
Restricted access peculiar phenotypic and cytotoxic features of pulmonary mucosal CD8 T cells in people living with HIV receiving long-term antiretroviral therapy.
O Meziane, Y Alexandrova, R Olivenstein, FP Dupuy… - 2021 - cabidigitallibrary.org
People living with HIV have high burdens of chronic lung disease, lung cancers, and
pulmonary infections despite antiretroviral therapy (ART). The rates of tobacco smoking by
people living with HIV vastly exceed that of the general population. Furthermore, we showed
that HIV can persist within the lung mucosa despite long-term ART. As CD8 T cell cytotoxicity
is pivotal for controlling viral infections and eliminating defective cells, we explored the
phenotypic and functional features of pulmonary versus peripheral blood CD8 T cells in ART …
pulmonary infections despite antiretroviral therapy (ART). The rates of tobacco smoking by
people living with HIV vastly exceed that of the general population. Furthermore, we showed
that HIV can persist within the lung mucosa despite long-term ART. As CD8 T cell cytotoxicity
is pivotal for controlling viral infections and eliminating defective cells, we explored the
phenotypic and functional features of pulmonary versus peripheral blood CD8 T cells in ART …