Development of CAR-T cells for long-term eradication and surveillance of HIV-1 reservoir
B Liu, W Zhang, H Zhang - Current opinion in virology, 2019 - Elsevier
Human immunodeficiency virus type 1 (HIV-1) reservoir is a pool of latently infected cells
harboring replication-competent proviral DNA that limits antiretroviral therapy. Suppression
of HIV-1 by combination antiretroviral therapy (cART) delays progression of the disease but
does not eliminate the viral reservoir, necessitating lifetime daily administration of
antiretroviral drugs. To achieve durable suppression of viremia without daily therapy, various
strategies have been developed, including long-acting antiretroviral drugs (LA-ARVs) …
harboring replication-competent proviral DNA that limits antiretroviral therapy. Suppression
of HIV-1 by combination antiretroviral therapy (cART) delays progression of the disease but
does not eliminate the viral reservoir, necessitating lifetime daily administration of
antiretroviral drugs. To achieve durable suppression of viremia without daily therapy, various
strategies have been developed, including long-acting antiretroviral drugs (LA-ARVs) …