[HTML][HTML] A single residue within the V5 region of HIV-1 envelope facilitates viral escape from the broadly neutralizing monoclonal antibody VRC01
D Guo, X Shi, KC Arledge, D Song, L Jiang, L Fu… - Journal of Biological …, 2012 - ASBMB
VRC01, a broadly neutralizing monoclonal antibody, is capable of neutralizing a diverse
array of HIV-1 isolates by mimicking CD4 binding with the envelope glycoprotein gp120.
Nonetheless, resistant strains have been identified. Here, we examined two genetically
related and two unrelated envelope clones, derived from CRF08_BC-infected patients, with
distinct VRC01 neutralization profiles. A total of 22 chimeric envelope clones was generated
by interchanging the loop D and/or V5 regions between the original envelopes or by single …
array of HIV-1 isolates by mimicking CD4 binding with the envelope glycoprotein gp120.
Nonetheless, resistant strains have been identified. Here, we examined two genetically
related and two unrelated envelope clones, derived from CRF08_BC-infected patients, with
distinct VRC01 neutralization profiles. A total of 22 chimeric envelope clones was generated
by interchanging the loop D and/or V5 regions between the original envelopes or by single …