Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease
The Lancet, 2000•thelancet.com
We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived
Zonula occludens toxin, which induces tight junction disassembly and a subsequent
increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin
expression was raised in intestinal tissues during the acute phase of coeliac disease, a
clinical condition in which tight junctions are opened and permeability is increased.
Zonula occludens toxin, which induces tight junction disassembly and a subsequent
increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin
expression was raised in intestinal tissues during the acute phase of coeliac disease, a
clinical condition in which tight junctions are opened and permeability is increased.
Summary
We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.
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