[HTML][HTML] Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial
RT Scott Jr, KM Upham, EJ Forman, T Zhao, NR Treff - Fertility and sterility, 2013 - Elsevier
Objective To determine if cleavage-or blastocyst-stage embryo biopsy affects reproductive
competence. Design Paired randomized clinical trial. Setting Academic-assisted
reproduction program. Patient (s) Attempting conception through IVF. Intervention (s) After
selecting two embryos for transfer, one was randomized to biopsy and the other to control.
Both were transferred within shortly thereafter. The biopsy was submitted for microarray
analysis and single-nucleotide polymorphism (SNP) profiling. Buccal DNA obtained from the …
competence. Design Paired randomized clinical trial. Setting Academic-assisted
reproduction program. Patient (s) Attempting conception through IVF. Intervention (s) After
selecting two embryos for transfer, one was randomized to biopsy and the other to control.
Both were transferred within shortly thereafter. The biopsy was submitted for microarray
analysis and single-nucleotide polymorphism (SNP) profiling. Buccal DNA obtained from the …