Central role of ILT3 in the T suppressor cell cascade
N Suciu-Foca, R Cortesini - Cellular immunology, 2007 - Elsevier
CD8+ T suppressor cells differentiate both in vivo and in vitro upon chronic exposure of
responding T cells to allogeneic APC. These Ts are allospecific and exhibit their function
interacting directly with priming APC which they render tolerogenic. Tolerogenicity of
professional and non-professional human APC, such as dendritic cells and endothelial cells,
respectively is due to the upregulation of the inhibitory receptors ILT3 and ILT4. ILT3 signals
both intracellularly, inhibiting NF-κB activation, and transcription of costimulatory molecules …
responding T cells to allogeneic APC. These Ts are allospecific and exhibit their function
interacting directly with priming APC which they render tolerogenic. Tolerogenicity of
professional and non-professional human APC, such as dendritic cells and endothelial cells,
respectively is due to the upregulation of the inhibitory receptors ILT3 and ILT4. ILT3 signals
both intracellularly, inhibiting NF-κB activation, and transcription of costimulatory molecules …
