Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation.
HM Temin - Proceedings of the National Academy of …, 1993 - National Acad Sciences
HM Temin
Proceedings of the National Academy of Sciences, 1993•National Acad SciencesHuman immunodeficiency virus variation is extensive and is based on numerous mistakes in
reverse transcription. All retrovirus replication requires two strand transfers (growing point
jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse
transcription are the result of this requirement for the two strand transfers needed to form the
provirus.
reverse transcription. All retrovirus replication requires two strand transfers (growing point
jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse
transcription are the result of this requirement for the two strand transfers needed to form the
provirus.
Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.
National Acad Sciences
