We describe the case of a 24-year-old female with end-stage renal disease from focal
segmental glomerulosclerosis (FSGS) diagnosed at age 16, who underwent monozygotic
triplet transplantation at age 21 from her sister. Monozygosity was established by buccal
smear DNA PCR amplification using short tandem repeat (1) profiling for 16 genetic alleles.
All immunosuppression was discontinued by 1 month posttransplant. To evaluate the use of
immunosuppression in HLA identical monozygotic transplantation, we interrogated the …