A single amino acid mutation in the envelope cytoplasmic tail restores the ability of an attenuated simian immunodeficiency virus mutant to deplete mucosal CD4+ T …
MW Breed, APO Jordan, PP Aye, C Sugimoto… - Journal of …, 2013 - Am Soc Microbiol
Journal of virology, 2013•Am Soc Microbiol
Disruption of the conserved motif GYxxØ in the simian immunodeficiency virus (SIV)
SIVmac239 envelope (Env) cytoplasmic tail resulted in a virus (ΔGY) that exhibited a high
plasma peak but uniquely failed to acutely deplete mucosal CD4+ T cells. Here, we show
that ΔGY containing a flanking S727P mutation that was acquired in ΔGY-infected
macaques reacquired the ability to rapidly deplete CD4+ T cells in lamina propria. This
suggests that the GYxxØ motif and S727P each contribute to SIV's targeting to mucosal …
SIVmac239 envelope (Env) cytoplasmic tail resulted in a virus (ΔGY) that exhibited a high
plasma peak but uniquely failed to acutely deplete mucosal CD4+ T cells. Here, we show
that ΔGY containing a flanking S727P mutation that was acquired in ΔGY-infected
macaques reacquired the ability to rapidly deplete CD4+ T cells in lamina propria. This
suggests that the GYxxØ motif and S727P each contribute to SIV's targeting to mucosal …
Abstract
Disruption of the conserved motif GYxxØ in the simian immunodeficiency virus (SIV) SIVmac239 envelope (Env) cytoplasmic tail resulted in a virus (ΔGY) that exhibited a high plasma peak but uniquely failed to acutely deplete mucosal CD4+ T cells. Here, we show that ΔGY containing a flanking S727P mutation that was acquired in ΔGY-infected macaques reacquired the ability to rapidly deplete CD4+ T cells in lamina propria. This suggests that the GYxxØ motif and S727P each contribute to SIV's targeting to mucosal tissues.
American Society for Microbiology