Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma
Background: Single nucleotide polymorphisms in the myosin light chain kinase (MYLK)
gene have been implicated in the risk of sepsis-related acute lung injury and asthma. MYLK
encodes protein isoforms involved in multiple components of the inflammatory response,
including apoptosis, vascular permeability, and leukocyte diapedesis. We tested the
association of MYLK gene variation in the development of acute lung injury in major trauma
patients. Methods: We conducted a prospective cohort study of 273 subjects with major …
gene have been implicated in the risk of sepsis-related acute lung injury and asthma. MYLK
encodes protein isoforms involved in multiple components of the inflammatory response,
including apoptosis, vascular permeability, and leukocyte diapedesis. We tested the
association of MYLK gene variation in the development of acute lung injury in major trauma
patients. Methods: We conducted a prospective cohort study of 273 subjects with major …