[HTML][HTML] CCAAT enhancer-binding protein α is a molecular target of 1, 25-dihydroxyvitamin D3 in MCF-7 breast cancer cells
P Dhawan, R Weider, S Christakos - Journal of biological chemistry, 2009 - ASBMB
Numerous studies have shown that the active form of vitamin D, 1, 25 (OH) 2 D 3, can exert
growth inhibitory effects on human breast cancer cells and mammary tumor growth.
However, the molecular mechanisms remain to be fully delineated. This study demonstrates
for the first time that CCAAT enhancer-binding protein α (C/EBPα), a member of the C/EBP
family of transcription factors, is induced by 1, 25 (OH) 2 D 3 and is a potent enhancer of
VDR transcription in MCF-7 breast cancer cells. 1, 25 (OH) 2 D 3 was found to induce …
growth inhibitory effects on human breast cancer cells and mammary tumor growth.
However, the molecular mechanisms remain to be fully delineated. This study demonstrates
for the first time that CCAAT enhancer-binding protein α (C/EBPα), a member of the C/EBP
family of transcription factors, is induced by 1, 25 (OH) 2 D 3 and is a potent enhancer of
VDR transcription in MCF-7 breast cancer cells. 1, 25 (OH) 2 D 3 was found to induce …