Diabetic neuropathy is a major complication of diabetes that results in the progressive
deterioration of the sensory nervous system. Mitochondrial dysfunction has been proposed
to play an important role in the pathogenesis of the neurodegeneration observed in diabetic
neuropathy. Our recent work has shown that mitochondrial dysfunction occurs in dorsal root
ganglia (DRG) sensory neurons in streptozotocin (STZ) induced diabetic rodents. In
neurons, the nutrient excess associated with prolonged diabetes may trigger a switching off …