Clinicopathologic features of BRCA-linked and sporadic ovarian cancer
J Boyd, Y Sonoda, MG Federici, F Bogomolniy, E Rhei… - Jama, 2000 - jamanetwork.com
ContextMost hereditary ovarian cancers are associated with germline mutations in BRCA1
or BRCA2. Attempts to define the clinical significance of BRCA mutation status in ovarian
cancer have produced conflicting results, especially regarding survival. ObjectiveTo
determine whether hereditary ovarian cancers have distinct clinical and pathological
features compared with sporadic (nonhereditary) ovarian cancers. Design and
SettingRetrospective cohort study of a consecutive series of 933 ovarian cancers diagnosed …
or BRCA2. Attempts to define the clinical significance of BRCA mutation status in ovarian
cancer have produced conflicting results, especially regarding survival. ObjectiveTo
determine whether hereditary ovarian cancers have distinct clinical and pathological
features compared with sporadic (nonhereditary) ovarian cancers. Design and
SettingRetrospective cohort study of a consecutive series of 933 ovarian cancers diagnosed …
