Age dependent course of EAE in Aire−/− mice
This study explores the consequences of deficiency in the autoimmune regulator (Aire) on
the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased
susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6 month
old mice. In contrast, 2 month old Aire KO mice were less susceptible to EAE than WT mice,
and this age-related resistance correlated with elevated proportions of T regulatory (Treg)
cells in their spleen and brain. Combined with our previous findings in experimental …
the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased
susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6 month
old mice. In contrast, 2 month old Aire KO mice were less susceptible to EAE than WT mice,
and this age-related resistance correlated with elevated proportions of T regulatory (Treg)
cells in their spleen and brain. Combined with our previous findings in experimental …